Salvia rumour

ok, ill kill myself and tell youll if i tripp out

Except it's not tripping when you won't be coming back. You'll just be whatever the fuck it is when you are at that level. Not human anymore... Ok, so lets get this show on the road.

Quote:

---

Originally Posted by CocaCola

That could be said about alot of substances though. DMT and Ketamine for example. In my opinion, this rumor is more suited to those drugs then Salvia... as Salvia is jsut over the top ridiculous. It's more like you enter the realm of Loki the God of Mischief!

---

damn straight
the state you enter right before you die is much discussed.
the natural DMT of the banesteriopsis caapi with the psychotria viridis has been suggested too alongside salvia to have a very significant, yet unresolved effect on the stream of impulses coming into the brain.
The "death" part, or as CocaCola nicely put it "the realm of Loki" :p seems to be some sort of extravagant increase in use of braincells. Whereas we only use 10 to 15% of our brain being sober, higher activity has been scientifically proven on drugs like LSD, Psilocybin, both natural and pharmahuasca, adrenaline, etc..
So if death produces a similar boost of conciousness, we might experience a high not to be taken lightly.
Or as i like to call it, a nice mental Hard-On :smokin:

Quote:

---

Originally Posted by syrrus

Ummm....that sounds like a load of crap. From what ive come to understand salvinorin a is a powerful seretonal inhibitor and hallucinagenic replacement. Science barely knows anything about the drug and has no idea how it affects the brain. They do know that it leaves no lasting affect after it's use besides the profound memory of it's effects. If you hear anything about how salvia works, just be safe and don't believe it because there isn't much research going on about the plant at all short of growers trying to increase potency. Just do your research, like I know this kid that keeps on telling people that the reason that you trip out on LSD is because your brain bleeds and the pressure of the bleeding causes hallucinations. See modern american drug culture is full of 90% bullshit.

---

Actually, salvia is not as big of a mystery as it once was. I assume you're talkin' about serotonin in that first sentence, in which case your understanding of how salvia works is incorrect. Salvinorin-a (main active ingredient in salvia divinorum) is a kappa opioid receptor agonist, meaning that it binds to the kappa opioid receptors and triggers a response in the cells that those receptors are on. Kappa opioid receptors like most if not all receptors in our bodies have corresponding naturally occuring substances (endogenous ligands) that bind to them, for Kappa opioid receptors those substances are dynorphins.

http://en.wikipedia.org/wiki/Salvia_divinorum

http://www.pubmedcentral.nih.gov/art...medid=12192085

Quote:

---

Originally Posted by Edgar

Actually, salvia is not as big of a mystery as it once was. I assume you're talkin' about serotonin in that first sentence, in which case your understanding of how salvia works is incorrect. Salvinorin-a (main active ingredient in salvia divinorum) is a kappa opioid receptor agonist, meaning that it binds to the kappa opioid receptors and triggers a response in the cells that those receptors are on. Kappa opioid receptors like most if not all receptors in our bodies have corresponding naturally occuring substances (endogenous ligands) that bind to them, for Kappa opioid receptors those substances are dynorphins.

http://en.wikipedia.org/wiki/Salvia_divinorum

http://www.pubmedcentral.nih.gov/art...medid=12192085

---

Edgar stop ruining everyone's fun.

Seriously folks, drugs are where you go when you die.

Continue discussion.

lolz
My bad.

Quote:

---

Originally Posted by Edgar

Actually, salvia is not as big of a mystery as it once was. I assume you're talkin' about serotonin in that first sentence, in which case your understanding of how salvia works is incorrect. Salvinorin-a (main active ingredient in salvia divinorum) is a kappa opioid receptor agonist, meaning that it binds to the kappa opioid receptors and triggers a response in the cells that those receptors are on. Kappa opioid receptors like most if not all receptors in our bodies have corresponding naturally occuring substances (endogenous ligands) that bind to them, for Kappa opioid receptors those substances are dynorphins.

http://en.wikipedia.org/wiki/Salvia_divinorum

http://www.pubmedcentral.nih.gov/art...medid=12192085

---

We know this... but that isn't what we're discussing. We're discussing the spiritual nature of Salvia and other hallucinogens. Ketamine works through chemicals and receptors and shit too, of course, but that doesn't mean it doesn't share some aspects of an NDE.

My post was only a reply to syrrus' post, I'm intentionally staying out of the spiritual side of the discussion.

My mistake.