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View Full Version : Thoughts about this study regarding using creatine to mask a diluted sample



ringle101
03-12-2013, 11:03 AM
The dilution thread above suggests using creatine will mask the effects of dilution by raising one's creatinine levels. I found a study that seems to suggest creatine supplements have no effect on creatinine levels. Any thoughts?

Effect of Oral Creatine Supplementation on Random Urine Creatinine, pH, and Specific Gravity Measurements (http://www.clinchem.org/content/46/2/295.full)

"This short-term study investigated the effects of oral creatine supplementation on urinary creatinine, pH, and specific gravity values. Individual plots of all discrete urine specimen values did not reveal any apparent effect of creatine administration on these measurements. In conclusion, these data suggest that oral creatine supplementation administered at recommended daily doses does not influence routinely used urine integrity tests."

ringle101
03-12-2013, 11:17 AM
http://jat.oxfordjournals.org/content/34/1/39.full.pdf

and another study that comes to a similar conclusion

ringle101
03-12-2013, 11:18 AM
"The objective of this part of the study was to determine
whether creatine supplementation could increase the amount
of creatinine in human urine specimens even after hyper-hydration. People undergoing mandated drug screening sometimes consume a large volume of water prior to testing in an
attempt to wash away the presence of illicit water-soluble drugs
in the body. The tests showed that over the course of an 8-h period the creatinine concentration declined consistently without
any significant elevation even in participants who took creatine"

Burnt Toast
03-12-2013, 12:04 PM
The dilution thread above suggests using creatine will mask the effects of dilution by raising one's creatinine levels. I found a study that seems to suggest creatine supplements have no effect on creatinine levels. Any thoughts?

Effect of Oral Creatine Supplementation on Random Urine Creatinine, pH, and Specific Gravity Measurements (http://www.clinchem.org/content/46/2/295.full)

"This short-term study investigated the effects of oral creatine supplementation on urinary creatinine, pH, and specific gravity values. Individual plots of all discrete urine specimen values did not reveal any apparent effect of creatine administration on these measurements. In conclusion, these data suggest that oral creatine supplementation administered at recommended daily doses does not influence routinely used urine integrity tests."

N2's Dilution "sticky" doesnt say anything about following the RDA when doing any creatine-loading.

ringle101
03-12-2013, 12:14 PM
N2's Dilution "sticky" doesnt say anything about following the RDA when doing any creatine-loading.

Yeah, I found that part to be a little bit of flimsy methodology. The subjects in the first study took 5g four times a day if I remember correctly. N2 suggests "creatine loading" which doesn't really help clarify anything. From what I could find on bodybuilding.com a typical "creatine loading" regimen was around 20g daily and then 5g daily as maintenance so this seems to reflect what was done in the study (see: Bodybuilding.com - Creatine: Beyond The Confusion! (http://www.bodybuilding.com/fun/koch1.htm)).

Not really trying to attack N2's methods. I really hope they work effectively, just wanted to foster discussion about the fact that creatine may not be as effective as previously thought.