well i've taken 4 200 mg advil's and had a beer before that and had forgoten then i smoked a bowl and i felt really sick like my chest hurt and i was pale my friend said so idk but i have taken 2 vicodin and a few beers and then smoke a few bowls and i am fucked i think the combination does it but i don't think it is too safe so i try not to do that too much but i think it depends on the user