Definitely any line from Grandma's Boy. More specifically, the scene with the monkey when Alex and Dante are smoking and Alex says to the monkey after taking a hit, "Don't judge me monkey." Or when Dante says, "I'll smoke it with ya bro, we'll go to the looney bin together, I don't give a shit." All classic. Lock, Stock, and Two Smoking Barrels has some good ones like, "We grow copious amounts of ganja, yah. And you're carrying a wasted girl and a bag of fertilizer. You don't look like your average horti-fucking-culturalist!"