Where the Buffalo Roam.
Basically take Fear and Loathing, replace Johnny Depp with Bill Murray, give it somewhat of a story (pretty much about gun running and throwing huge parties in hotel and hospital rooms), take it out of Las Vegas and film it in 1980. If you haven't seen this and you're not really a huge Johnny Depp fan(because Johnny Depp fans tend to be aggressive and unaccepting, therefore they probably wouldn't like the fact that Bill Murray was the first to portray HST on film), then go watch this shit. It's hilarious.