I took WellbutrinSR and am an everyday smoker. I don't know if this was the cause but I had a nervous breakdown while taking it (I was not high when it happened). I've taken plenty of other mood altering meds, but never had reactions similar to what I experienced with Wellbutrin. It made me worse. You have to wean yourself off that stuff if I remember correctly...you can't just stop taking it....becareful and see you doc right away. Good Luck, and I hope that you find a med that works for you. Bree