I knew a guy in college who was allergic like that and broke out in hives. He mouth would also swell. I always thought it was partially because of nervousness on his part, too, but it happened even when he wasn't nervous. He finally gave up on smoking.

I had eye allergies, runny nose, and itchy throat and ears when I smoked, but a couple of antihistamines would keep that under control so it wasn't a problem.