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01-22-2007, 02:58 AM #8
Senior Member
What do you know about Lou Gehrigs Disease?
Hi geo...thought I'd post this article about ALS and medical Marijuana for you to read. The tests in animals are very promising.
You might get your mom to try a canna butter it is easy to make and use or a vape. There are so many ALS patients using MM and getting away from the pain medicines. Those pain meds are really hard of the body. There are a lot of ALS support groups online that talk about marijuana use. I hope these help a little.
A review of the scientific literature reveals an absence of clinical trials investigating the use of cannabinoids for ALS treatment. However, recent preclinical findings indicate that cannabinoids can delay ALS progression, lending support to anecdotal reports by patients that cannabinoids may be efficacious in moderating the disease’s development and in alleviating certain ALS-related symptoms such as pain, appetite loss, depression and drooling.[1]
Writing in the March 2004 issue of the journal Amyotrophic Lateral Sclerosis & Other Motor Neuron Disorders, investigators at the California Pacific Medical Center in San Francisco reported that the administration of THC both before and after the onset of ALS symptoms staved disease progression and prolonged survival in animals compared to untreated controls.[2]
Additional trials in animal models of ALS have shown that the administration of other naturally occurring and synthetic cannabinoids can also moderate ALS progression, but not necessarily impact survival.[3-4] One recent study demonstrated that blocking the CB1 cannabinoid receptor did extend life span in an ALS mouse model, suggesting that cannabinoids’ beneficial effects on ALS may be mediated by non-CB1 receptor mechanisms.[5]
Preclinical data has also shown that cannabinoids are neuroprotective against oxidative damage both in vitro[6] and in animals.[7] Cannabinoids’ neuroprotective action may be able to play a role in moderating ALS, which is characterized by excessive glutamate activity in the spinal cord.[8] At least one cannabinoid, delta-9-THC, has been shown to protect cultured mouse spinal neurons against excitotoxicity.[9]
As a result, some experts now recommend that “marijuana … be considered in the pharmacological management of ALS,”[10] and they believe that “further investigation into the usefulness of marijuana and … synthetic cannabinoid receptor agonists is warranted.”[11]
Ride For Life | News Center | Marijuana-like Drugs Help Treatment of Nervous System Diseases
Amyotrophic Lateral Sclerosis (ALS) - NORML
[M]arijuana has now been shown to have strong antioxidative and neuroprotective effects, which may prolong neuronal cell survival. From a pharmacological perspective, marijuana is safe with minimal possibility of overdose. In states where it is legal to do so, marijuana should be considered in the pharmacological management of ALS. ” The article also noted: “[Cannabinoids] will vaporize at a temperature much lower than actual combustion. Heated air can be drawn through marijuana and the active compounds will vaporize, which can then be inhaled … Theoretically, this removes most of the health hazards of smoking.”
— Carter, Gregory T. Rosen, Bill S., “Marijuana in the Management of Amyotrophic Lateral Sclerosis,” American Journal of Hospice and Palliative Care, July/August 2001
The MDA/ ALS Newsletter 8-12 | MDA
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