no its not difficult just read up on it and get some rooting gel or powder and keep it simple with a seedling tray with dome you have plenty of time.
yes they will all be female from a female plant so usually wait until they show sex before even taking clones wich is usually 4-8 weeks old and you wont be able to take alot of clones from that age of plant without completly killing it, but you will be able to get 4-5 without a problem and as the plant gets bigger you will be able to take more clones from it at a time, if you dont have any indoor plants now that you can use for this spring for taking clones then would plan on starting some soon like in january so you have time to veg it long enough to show sex and root cuttings.