ive done it, the shrink doctors had me on antidepressants and shit for bipolar and the pills made me gain weight.
then i quit using them, started eating just one meal a day and started smoking a whole lot more weed. weed raises the metabolism (i think, i could be wrong) and the heightened metablic rate plus the lack of food forced my body to consume its fat reserves and im now skinny as a mofo. i still only eat one meal a day.