Ok, 2 one hitter bowls into this smoking session, I'm pretty damn high. The high does feel slightly different than normal, hard to really put my finger on it. Either it works or its a placebo effect, either way, its cool. Its not an overwhelming difference, but noticeable. Then again, I picked mine up from wal-mart, and while I was looking up where to get it, it said wal-mart wasn't the best brand on some medical forums. I'll have to look it up again and post the brand that doctor recommended. Once I run out of this shit, I'll try a different kind. Give it a shot. 5-htp actually has other uses too.