If we see nature as a machine rather than a part of ourselves, we're more likely to take on the attitude that it needs to be subdued and conquered, rather than respected and commutually cared for.
I don't think anyone can really escape the sense of isolation. One might come to the realization that it's all an integrated whole, but as long as we're down here stuck within our minds, that isolation is going to be a dominant factor. Interesting to speculate how far we can take it though, and what integration could mean on down the road. Maybe we'll die off and our machines will be running the show? Maybe that's already happened to somene/something else and that is going on now? Bigger speculations than my imagination can handle...lol

I think we're at a crossroads where your attitude shift is taking place. After all, the initial step was subdueing and conquering Nature. I, for one am rather glad to be at the top of the food chain where I don't have to worry about being eaten by lions, starved, or frozen by the elements. Now, finally we've reached to point where we can choose to be caretakers, or we'll loose our status and be right back at square one struggling for survival.