The VERY BEST game to play while on any drug is N2O, on the Playstation 1. It's this really intense spinning fighting game, with Crystal Method as the soundtrack.

Bonus: It's so old, it's probably only 5 bucks.

See also: Castlevania:Symphony of the Night. This game is by far, hands down the most entertaining video game int he history of gaming. Also, probably 5 bucks.