theyres some prescription anti-depressants and anti anxiety meds that mess around and change the amounts of certain chemicals in your body, i would think that it would change the high. a friend of mine is on some sort of med like that and he trips out when he smokes, even a little.

maybe it has something to do with MAOI's i know they affect how alot of drugs work on you.

oh and "uppers" doesnt only reffer to pills, coke, caffine, cigs and pretty much anything that wakes you UP or gives you energy i would consider an UPper

weed on the other hand is a downer like heroin and alcohol
XIII Reviewed by XIII on . Uppers tone down weed high? i have been smoking for a while and im wondering if anyone els has noticed this, when i smoke alot and get retarded to the point where i have trouble walking streight, if i smoke a ciggarette it brings me back to the point of just being "high" and not super baked. for a while i thought it was just that the weed we where getting wasnt that great, or my tollerance was too high, or i wasnt holding my hits long enough.. but after noticing things i belive the reason i dont usualy get as high as i Rating: 5