OK, so i'm building myself a medical marijuana note book (over 200 pages of medical abstracts) and from ccicnewsletter (HEAVY MMJ research) I got this. I know you guys already know this from personal experience, but having it said by the medical research community is also very good. You might want to print a copy for when your state finally allows MMJ and you go in to get your recommendation.

Effects of a Cannabinoid Agonist on Spinal Nociceptive Neurons in a Rodent Model of Neuropathic Pain

Liu, C. and J. M. Walker (2006). J Neurophysiol, Aug 30.



The effects of the synthetic cannabinoid WIN 55,212-2 on heat-evoked firing of spinal wide dynamic range (WDR) neurons were examined in a rodent model of neuropathic pain. Fifty-eight WDR neurons (1 cell/animal) were recorded from the ipsilateral spinal dorsal horns of rats with chronic constriction injury (CCI) and sham-operated controls. Relative to sham-operated controls, neurons recorded in CCI rats showed elevations in spontaneous firing, noxious heat-evoked responses, and after discharge firing as well as increases in receptive field size. WIN 55,212-2 (0.0625 mg/kg, 0.125 mg/kg, 0.25 mg/kg, i.v.) dose-dependently suppressed heat-evoked activity and decreased the receptive field areas of dorsal horn WDR neurons in both nerve injured and control rats with a greater inhibition in CCI rats. At the dose of 0.125 mg/kg, i.v., WIN 55,212-2 reversed the hyperalgesia produced by nerve injury. The effect of i.v. administration of WIN 55,212-2 appears to be centrally mediated because administration of the drug directly to the ligated nerve did not suppress the heat-evoked neuronal activity in CCI rats. Pretreatment with the cannabinoid CB1 receptor antagonists SR141716A or AM251, but not the CB2 antagonist SR144528, blocked the effects. These results provide a neural basis for reports of potent suppression by cannabinoids of the abnormal sensory responses that result from nerve injury.

http://ccicnewsletter.com/index.php?...#_Toc148951557


My nerve problems stem from a childhood head injury- kid tried to kill me with a hammer. Ended up with migraines and cluster headaches, a large, sometimes painful, scar in my scalp and a half dozen dents in my skull. Cannabis keeps the headaches away. I've been using it for 40 years. I'm "California legal". I can't even imagine what it would be like to have my scar all over my body. Even thinking about it makes me shudder! I wish you all the best of luck in life- it seems to me you've had your lifetime's worth of bad luck already.
Storm Crow Reviewed by Storm Crow on . burns/amputations / phantom pain hey folks , i'm a newcomer to your site and am curious if there are other medicinal users due to severe burns , or phantom pain due to amputations ? i'm in michigan and am lucky enuf to be in 1 of only 4 cities that overlooks medicinal use as long as you have a script / or letter from a dr. i'm an 85% 3rd. degree burn survivor , therefore the xcrispi bit , and am missing numerous fingers n toes due to my injuries from an auto related accident . kidney probs. prohibit the Rating: 5