I'm sure the official response should always be a discouragement of drinking, and that's for good reason. If you're taking an antidepressant, you're counter-acting its effects by ingesting ethyl alcohol, which is a depressant, even if you only drink once in a blue moon.

But I know that's also not reality. If you're not overdoing it and taxing your liver with binge drinking, you can probably get by with occasional infrequent drinking. Don't be surprised if it affects the action of your Lexapro though. Keep up that water and be very careful. No drinking and driving, right?