Cas got the reason right. Some people's cannabinoid receptors have to be awakened. And some are downright resistant to it. This resistance happens with other drugs, too. It often takes several exposures to weed before some people will start to feel its effects.
birdgirl73 Reviewed by birdgirl73 on . What causes the first time to have no effect? I have a close friend, and we may have an opportunity in a month to have her smoke for the first time (Her parents are very strict and we're going to a concert which will take all day). It is the only opportunity we will have for a while, so I want to make sure it works for her the first time. I do know that many first-time users don't get high, so what I would like to know is, what are some things we can do to lessen the chance of her not getting high the first time? Thanks in Rating: 5