Youd need to give more information. If you are a beginner, Id buy a fender guitar and a line 6 amp because fenders are easy to play and line 6's make it easy to be creative so both tend to be inviting to new players. If you've been playing a while and want to upgrade, it all depends on what style you play but I think you can't go wrong with an epiphone. I'd also get a cheap tube practice amp if I were you. I play a Gibson hollowbody through a fender tube amp and have about 7 stomp boxes I use. I've also got a fender american strat, a Marshall practice amp, a Martin acoustic, and a nice Yamaha Keyboard.