Out of all the games I have, the only one that the girls I know have been able to actually pick up and play (besides Super Mario, WHA WHA!) is Fable. Because it's really simplistic. You can just walk around and kill stuff, lol.

Grand Theft Auto might be fun for you, too, maybe...?

And if all else fails, my friend, just get a cool version of Tetris and have at it!