Here, you want some serious shit???

[beachguy in thongs]

...this statement.

Recently, cannabinoid receptor agonists have been reported to impair prepulse inhibition (PPI) of the startle reflex. In the current study, we examined the effect of Delta(9)-tetrahydrocannabinol (THC), the principal psychoactive component of cannabis, on the PPI, and found that THC (10 mg/kg, i.p.) impaired the PPI concomitant with a decrease in the startle response. Antipsychotics such as haloperidol (0.3 mg/kg, i.p.) and risperidone (0.1 mg/kg, i.p.), which are potent dopamine D(2) receptor antagonists, and SR141716 (10 mg/kg, i.p.), a CB(1) cannabinoid receptor antagonist, reversed these THC-induced PPI deficits. Moreover, THC (10 mg/kg) increased dopamine (DA) release in the nucleus accumbens but not medial prefrontal cortex over a 50-100-min period (time of PPI test) after treatment, and SR141716 (10 mg/kg) reversed this increase in DA release induced by THC. These results suggest that dopaminergic hyperfunction in the nucleus accumbens may be involved in THC-induced PPI deficits.

beachguy in thongs Reviewed by beachguy in thongs on 07-06-2006. Here, you want some serious shit??? Fuck off. 11,000 meaningful posts. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16318877&query_hl=1 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=full_report&list_uids=9290 http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604107 http://www.ebi.uniprot.org/entry/Q9Y2T6 GPR55 found to be a CB receptor. Rating: 5