First of all, why do you think mood and setting have such an impact on your trip or your high? It is effecting your anxiety/depression because pot for the most part exacerbates your mood, feelings and so on. So you if you are "pre-wired" or prone to being anxious or depressed, you better believe pot effects it. So, it may not be the sole cause of your anxiety and depression, but it seems to obviously bring it out. Anyway, I hope your feeling better Noleaf... Maybe try burning again when your feeling good about things consistently. Cheerio!