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Scientists have unveiled an unlikely weapon in the battle against the
bulge: cannabis. More specifically, one of its key ingredients, which has
been found to suppress appetite.

Anyone who has ever inhaled will know the feeling: an inescapable desire to
eat everything in sight, a state called the munchies. It stems from the
action of tetrahydrocannabinol (THC), one of the active ingredients in
cannabis, on specific appetite-control receptors in the brain. The chemical
also causes the body to lay down more fat.

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But Roger Pertwee, a neuropharmacologist at Aberdeen University, said
yesterday at the British Association festival of science that there is more
to the cannabis story.

"We've discovered to our surprise that cannabis, as well as containing a
drug that boosts appetite, contains a drug which has a blocking effect,"
said Professor Pertwee. "The work so far has been working with tissue and
we've yet to see what this drug does when we give it to a whole organism
and what it does when we give it to humans."

The drug, known as tetrahydrocannabivarin (THCV), works on the same
receptors as THC but has entirely the opposite effect. The research will be
published in the British Journal of Pharmacology.

THCV is not the first appetite suppressant to be inspired by cannabis. The
drug Rimonabant works by blocking the brain receptors that the body's own
cannabinoid compounds - released when we comfort eat - attach themselves
to. Because the cannabinoids do not reach the receptors in a person taking
Rimonabant, they will feel less compulsion to eat.

Why THCV does not manifest itself to people who smoke cannabis is a
mystery, but Prof Pertwee said it might have something to do with the
proportions of the various ingredients in the drug. "The relative
proportions of THC and THCV vary from cannabis to cannabis," he said.

"There is a large amount of THCV in Pakistani cannabis, which is the one
used to make a medicine called 'tincture of cannabis'. That contained about
equal amounts of THC and THCV."

Prof Pertwee said that there were several promising medicinal compounds to
be derived from cannabis, both for boosting the effects of the body's own
cannabinoids and for blocking them.

Boosting the cannabinoids could bring pain relief, for example, and relieve
spasms for sufferers of multiple sclerosis. Prof Pertwee added that there
was also evidence that the compounds had a protective effect against cancer.

As well as controlling appetite, developing drugs that block the body's
cannabinoids could help people to quit smoking by stopping nicotine having
any effect on the brain.

PEACE TO ALL!
co dee Reviewed by co dee on . Anyone ever heard of THCV??? I'm told that south african sativas have a special type of THC called THCV that produces a high that is visually stimulating and almost hallucinogenic. Wondering if anyone else has heard this or if its just a rumor. Well I hope its true anyway..... I just started a few Malawi Gold seeds and I'm hoping the 112 day flowering is going to be worth the wait. Rating: 5