Quote Originally Posted by THE MEDIC
beachguy, do you mean like...CB2/immunesystem/bodyhigh/indicas...CB1/retina-brain../headhigh/sativas???

This is from the...Behavioral effects of cannabinoid agents in animals
by
Chaperon F, Thiebot MH

"Most of the agonists exhibit nonselective affinity for CB1/CB2 receptors, and delta9-THC and anandamide probably act as partial agonists. Some recently synthesized molecules are highly selective for CB2 receptors, whereas selective agonists for the CB1 receptors are not yet available. A small number of antagonists exist that display a high selectivity for either CB1 or CB2 receptors."

I know its animals ,but.....
will goldfish eat bud??theres always a bud ready to eat your goldfish
http://www.cannabis.net/cb1/index.html

Yes, sort of, although CB1 receptors are found throughout the body (this 2002-released study says "expressed primarily in the brain and in some peripheral tissues" (Howlett et al., 2002; Pertwee and Ross, 2002)). CB2 "mainly" in the immune system.

This study does show a difference between the two receptors by administering a CB1 receptor antagonist and it did not affect the effects of the Cannabidiol:

The addition of CBD to the culture medium led to a dramatic drop of mitochondrial oxidative metabolism [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide test] and viability in glioma cells, in a concentration-dependent manner that was already evident 24 h after CBD exposure, with an apparent IC50 of 25 µM. The antiproliferative effect of CBD was partially prevented by the CB2 receptor antagonist N-[(1S)-endo-1,3,3-trimethylbicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528; SR2) and {alpha}-tocopherol. By contrast, the CB1 cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboximide hydrochloride (SR141716; SR1), capsazepine (vanilloid receptor antagonist), the inhibitors of ceramide generation, or pertussis toxin did not counteract CBD effects. We also show, for the first time, that the antiproliferative effect of CBD was correlated to induction of apoptosis, as determined by cytofluorimetric analysis and single-strand DNA staining, which was not reverted by cannabinoid antagonists.

First published on November 14, 2003
As with all studies, as a community, further research on this subject is suggested. Right now, I'm hot and have to turn up my air.
beachguy in thongs Reviewed by beachguy in thongs on . Physiological differences in Sativa/Indica stains Are there any? I've noticed that I only get red-eye when I smoke Sativa strains. Indica strains have no effect on my eyes. The same applies to my speech, coordination, etc. Anyone else noticed this? Or could it be a biological thing? Rating: 5