Physiological differences in Sativa/Indica stains

[willystylle]

Are there any?

I've noticed that I only get red-eye when I smoke Sativa strains. Indica strains have no effect on my eyes. The same applies to my speech, coordination, etc. Anyone else noticed this? Or could it be a biological thing?

willystylle Reviewed by willystylle on 06-02-2006. Physiological differences in Sativa/Indica stains Are there any? I've noticed that I only get red-eye when I smoke Sativa strains. Indica strains have no effect on my eyes. The same applies to my speech, coordination, etc. Anyone else noticed this? Or could it be a biological thing? Rating: 5

[Breukelen advocaat]

Are there any?

I've noticed that I only get red-eye when I smoke Sativa strains. Indica strains have no effect on my eyes. The same applies to my speech, coordination, etc. Anyone else noticed this? Or could it be a biological thing?

I'd be glad to test this theory out if you'll send some samples. :dance:

[1234abcd]

I'd be glad to test this theory out if you'll send some samples. :dance:

LOL


I think your talking out BS, and you really dont know what your eyes look like. Take a look at the mirror next time you smoke an indica, and I guarantee you if you took a big enough rip, your eyes will go red on the outter part of them. The thing is, us stoners dont realize that our eyes are squinty and red, because we feel great when we're high, and really dont give a shit. If you are worried about the redness, just put a cleareye drop in each eye, and they will look way more white, and you will appear completely sober even tho you are totally fucked up. Also get gum for your breath, and wash the sticky icky off your finger tips, unless your lucky enough to have bought a nice hERb grinder..Damn I need one, but the one I want is 45..and damn .thats kinda alot for an herb grinder..maybe I can find it on ebay or something for cheaper but then I can't see what Imgetting

Well anyways I started bird walking because I type so fast, but to get back to topic, sativas tend to make me more wound up, while indicas help me relax, but ALL in ALL, if I take a big enough rip of either or, my eyes will get red. 420 4 LIFE

Also the redness is a good sign of how marijuana can help out medical ailments, for example people with Glaucoma (eye pressure) , smoke MJ, and it makes their eyes get bloodshot, while relaxing them , and relieving pressure..that is all that is happening when they are red..is that your brain is releasing pressure from the THC you just smoked...therefor redness occurs...and this happens with ALL potent flowers, hashish, oil, everything MJ!

[beachguy in thongs]

Are there any?

I've noticed that I only get red-eye when I smoke Sativa strains. Indica strains have no effect on my eyes. The same applies to my speech, coordination, etc. Anyone else noticed this? Or could it be a biological thing?

Leave it to good, old Erowid.
http://www.erowid.org/plants/cannabi...is_info6.shtml

Although, that link, I'm not sure, will answer your question.

[willystylle]

Thanks for the posts and thanks beachguy for the link... but sorry it didn't help.

What I mean is does anyone notice any differences in red-eye, cottonmouth and all the other shit when smoking different strains? I strongly believe that the indica strain does not give me red eyes while sativa strains do.

I don't bother with red-eye even when I have it - I just tell people dust/allergies/crying whatever and thats the end of it - but it would be interesting to note if anyone else has the same symptoms.

and 1234abcd, I do look in the mirror, its one of my weird habits when I get high, and no offence here but I think I know what I'm talking about as I'm describing myself.

[beachguy in thongs]

Another reason that your eyes can get bloodshot is lack of sleep. You can switch up your excuses, every once in a while.

[beachguy in thongs]

Okay, willy, I'll try and throw this out there. Maybe, someone else can help.

CB1 receptors have been detected in the retinas of numerous species, including salamander, goldfish, chick, rat, mouse, monkey, and human (Straiker et al. 1999a,b; Yazulla et al. 1999).

CB2 receptors are mainly in your immune system. That may be the target of Indicas, I don't know.

[THE MEDIC]

Okay, willy, I'll try and throw this out there. Maybe, someone else can help.

CB1 receptors have been detected in the retinas of numerous species, including salamander, goldfish, chick, rat, mouse, monkey, and human (Straiker et al. 1999a,b; Yazulla et al. 1999).

CB2 receptors are mainly in your immune system. That may be the target of Indicas, I don't know.

beachguy, do you mean like...CB2/immunesystem/bodyhigh/indicas...CB1/retina-brain../headhigh/sativas???

This is from the...Behavioral effects of cannabinoid agents in animals
by
Chaperon F, Thiebot MH

"Most of the agonists exhibit nonselective affinity for CB1/CB2 receptors, and delta9-THC and anandamide probably act as partial agonists. Some recently synthesized molecules are highly selective for CB2 receptors, whereas selective agonists for the CB1 receptors are not yet available. A small number of antagonists exist that display a high selectivity for either CB1 or CB2 receptors."


I know its animals ,but.....
will goldfish eat bud??theres always a bud ready to eat your goldfish
http://www.cannabis.net/cb1/index.html

[THE MEDIC]

Are there any?

I've noticed that I only get red-eye when I smoke Sativa strains. Indica strains have no effect on my eyes. The same applies to my speech, coordination, etc. Anyone else noticed this? Or could it be a biological thing?

I get red-eye no matter what strain I,m smoking....coughing, choking and a general taste of crap in my mouth came from some ill prepared (HOLY SHITTT their turning YELLOW!!!!!SPRAY'M!!!QUICK!!!) to the just plan ''I dont care how it comes out as long as it sells" kinda buds...they all gave me red-eye:stoned:

Indicas affect my eyes by keeping them closed thats why I wear shades...

[beachguy in thongs]

beachguy, do you mean like...CB2/immunesystem/bodyhigh/indicas...CB1/retina-brain../headhigh/sativas???

This is from the...Behavioral effects of cannabinoid agents in animals
by
Chaperon F, Thiebot MH

"Most of the agonists exhibit nonselective affinity for CB1/CB2 receptors, and delta9-THC and anandamide probably act as partial agonists. Some recently synthesized molecules are highly selective for CB2 receptors, whereas selective agonists for the CB1 receptors are not yet available. A small number of antagonists exist that display a high selectivity for either CB1 or CB2 receptors."

I know its animals ,but.....
will goldfish eat bud??theres always a bud ready to eat your goldfish
http://www.cannabis.net/cb1/index.html

Yes, sort of, although CB1 receptors are found throughout the body (this 2002-released study says "expressed primarily in the brain and in some peripheral tissues" (Howlett et al., 2002; Pertwee and Ross, 2002)). CB2 "mainly" in the immune system.

This study does show a difference between the two receptors by administering a CB1 receptor antagonist and it did not affect the effects of the Cannabidiol:

The addition of CBD to the culture medium led to a dramatic drop of mitochondrial oxidative metabolism [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide test] and viability in glioma cells, in a concentration-dependent manner that was already evident 24 h after CBD exposure, with an apparent IC50 of 25 µM. The antiproliferative effect of CBD was partially prevented by the CB2 receptor antagonist N-[(1S)-endo-1,3,3-trimethylbicyclo[2,2,1]heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyrazole-3-carboxamide (SR144528; SR2) and {alpha}-tocopherol. By contrast, the CB1 cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboximide hydrochloride (SR141716; SR1), capsazepine (vanilloid receptor antagonist), the inhibitors of ceramide generation, or pertussis toxin did not counteract CBD effects. We also show, for the first time, that the antiproliferative effect of CBD was correlated to induction of apoptosis, as determined by cytofluorimetric analysis and single-strand DNA staining, which was not reverted by cannabinoid antagonists.

First published on November 14, 2003

As with all studies, as a community, further research on this subject is suggested. Right now, I'm hot and have to turn up my air.