I have re-mothered (taken a clone of a clone) one plant several times a year since 1992. No sign of fading yet.

2000 years and we may see a change. Maybe.

The fact that each plant has it's own life cycle, and that each cutting may be at a different stage in that cycle may be the cause of the mutations. That and ferts and all the normal stuff.

As I understand it a clone of a clone of a clone of a clone of a clone of a clone of a clone of a clone is an EXACT copy of the first plant.

No?