To "run" them? You mean to shoot them up right? You could, but the binders in the pills can clog your veins, or cause an embolus, which could in turn cause a stroke or heart attack. or a blockage of blood flow to an area of the body. OCs have binders in them too, so they can cause the same thing. Pills are not meant to be injected, and doing so can, and has caused a lot of health problems for a lot of people, above and beyond the ill effects of shooting up something that is meant to be shot up.