No it doesn't put holes in your brain, thats a load of propaganda bullshit told to you to scare you from drugs.

However, you have to be responsible.

You can;t do it everyday and every weekend is too much, I keep it occasional for special events, gigs, festivals that kinda thing.

Anyway, you use up your seratonin supplies (feel good chemical that is naturally stored in the brain) because the E just makes your brain release a large amount of it at once (in very simple terms).

Hence why you should leave large gaps between using E to allow it to replenish itself.