Film:
Steve Buscemi (He's the man, period)
Takeshi Kitano (everything he touches is amazing)
Philip Seymour Hoffman (he commits and is amazing in even the littelest roles)

Music:
Richard D. James (he's just so intelligent and ahead of everybody, he has to be on my list)
Omar Rodriguez-Lopez (same as above but with a different genre)
Daniel Dumile aka MF Doom (his voice and style are the most original I've ever seen)