I'm interested in the same thing for the same reason.I don't want to have to run an airconditioner when I have my grow in a cool basement.Seems like a sealed room would be alotta extra work and equipment and$ etc. etc. I think you can run it .You have to time time your fans to coincide with your co2.Disperse it above your plants as it's heavier than air and sinks through yor canopy.I think you want a little air movement at certain spots to maximize co2 distributions.