I personaly think that 2ct2 is quite a bit edgier than 2c-i or 2c-e, and out of the many of my friends that I've shared this substance with - most either puked once or twice or were nauseated for the first couple of hours. I can't say that I agree with saying that 2ct2 doesn't last as long as other 2c's, IMHO longer. As far as which route of administration, I say orally because if you smoke it your just going to waste it and hardly feel anything. I would never do this but one friend of mine always vomited really bad off of 2ct2 and went the rectal route to avoid the nausea - I say fuck that, as long as I eat a few hours b4 dosing and divide my doses into two seperate smaller doses (spaced an hour apart) then I'm fine. An interesting side note: don't mix any of the 2c-t's with 5-meo-amt unless you want to trip balls for about 48 hours straight with 24-36 of those hours peaking. I handled the overload as well as I could, but my friend didn't fare so well and tried to kill his..., well nevermind let's just say the combo multiplies each other emensly - and I've verified this with t2, t4, t7, and t21. The combo might have been fun but the body load was very extreme involving muscle spasms and a general tweaked out feeling, and by the 24 hour mark I was begging to come down. Anyways, I advise to just take a small taste(couple mgs) first then gradually work your way up since you've never tried it before, after all every body reacts differently to these rc's, peace.