Quote Originally Posted by WeedLovingVeteran
1.The only reason it is baked in a cake or anything of the sort is to make it taste better.
2.Heating it in the oven will cause loss of some of the THC due to water vapour coming from the plant when evapourated.
3.Fat does not aid the digestion of THC as fat is broken down anyway by emulsification.
4.THC is an active chemical and does not need a catalyst.
5.Smoking weed is far more satisfying so why even attampt to eat it unless you are extremely stoned anyway and out for a laugh.
1) True
2) The loss of THC in water vapor is minimal, as it is not water soluble. If THC was lost in water, you would lose a ton of it when freshly harvested bud was dried and cured (which doesn;t happen).
3) THC is not digested at all. It is metabolized by isozymes in the liver (though it is active in its inherent form). In any event, lipoproteins are required to cross cellular phospholipid bilayers (plasma membranes) of vascular tissues (or any tissue for that matter) in order to enter systemic circulation. The lipoproteins are transport proteins, not digestive enzymes.
4) THC is active, yes, but it requires a catalyst (in this case a negative delta-H; AKA heat) to excite the valence electrons enough to form molecular bonds with the lipids, thus facilitating systemic distribution. This is an endothermic process in regard to the THC.

All words intended with respect. I just wanted to clarify my thoughts. If I am mistaken regarding this information, I have online subscriptions to PubMed, Medscape, and several research and biochemical journals I would be happy to consult if anyone can direct me to data that contradicts what I;ve mentioned...

Kindest,
D9