I would not want to roll without having some weed to bring me back up on the comedown. Weed and E go together like peas and carrots (on the come down and while waiting for it to kick in), at least for myself and everyone i know. Its best not to have acidy fruits just before and for a while after you take the pill. I used to always take a bunch of multi vitamins a couple of hours before taking the E. But then i read that doing that makes your stomach even more acidic and can thus hinder the effects of the E somewhat. Either way, taking the multivitamins at the end of the trip would be just as good, seeing as how the purpose is to ease the hangover effect and help you recover.