Antidepressants minimise the effect of E, or can even block its effects completely.
To be honest, if you're depressed I would even go near E, the comedowns are pretty fucking heavy and if your a little depressed already, then it isnt going to help things much.

I was doing so much E at one point when I was 18/19 that I ended up really depressed and was prescribed prozac - so if you're already depressed, just stay away!

And def stay away from E and uppers in general if you're taking MAOI inhibitors - it can be a fatal combination.
Oh, and off subject - I read yesterday that MAOI inhibitors really intensify DXM and DMT trips because they stop your body breaking down the active chemicals - I havent even taken these 2 drugs but to anyone who does - that info might be useful.

Anyway, if you're determined to do E - just remember it will probably be shit. I tried to get high while I was on prozac and it didnt work at all.