A single plant yes, you don't want to grow a single plant just in case it's mail though. Grow at the least 2 or 3. It also depends on the space your growing in. It is recommended that you have 50 lumens per square foot in your grow room, or at least a minimum of 20-30. A 250w HPS will probably give off around 30,000 lumens if I'm not mistaken? So in answer to your question, yes.