There is an absolute difference in taste in vegatables and fruits that are grown naturally than grown chemically. Sure the natural way promise smaller smaller fruits and vegatables but the taste is there. Think about giant strawberries at your local market, they look good but taste like shit.
My neighboor is a farmer and he says he grows naturally for his family's need, but he uses chemical ferts for the crops he sells. He says and I agree, organically grown crops are safer to consume wheras chemical fertilizers could lead to cancer. If weed is a plant, all above is also applicable for it.
I am using chemicals but if I had a bigger grow room I would definately go with organics.