Quote Originally Posted by BigBlock
relatively safely?
Several years ago, JW Olney discovered that dizocilpine (MK-801), a

chemical being tested to prevent brain damage from strokes, actually

caused damage to specific areas of the brain in rats. Since this time,

numerous other drugs in the same class (the dissociatives) have been

tested, and they all share this problem. As some of you might know, I

have spent a great deal of time trying to make sure that the Internet

community, and the larger world, has detailed information about this

complex, difficult-to-use, and often dangerous class of drugs. I first

learned of Olney's lesions a few years ago, but it has taken me much

time to review all the evidence, compare drug dosage within and across

species, speak to heavy dissociative users, and so on. I am now ready

to state my conclusions and make some recommendations, which are as

follows (explained in detail in the full document).



* Dissociatives definitely cause brain damage if used heavily.

One sub-anaesthetic "line dose" of ketamine, an equivalent dose of

PCP, or a third plateau DXM dose, is probably at least as damaging

to your brain as a few day "bender" on hard liquor, and possibly

more so because it affects specific areas of the brain.

* The risk of brain damage is worse the longer you stay high at any

given time; constant moderate-dose use is probably just as

damaging as a brief, high-dose use.

* Reaching the anaesthetic level is exceedingly hard on your brain.

* Ketamine is probably the least harmful, PCP the most, and DXM

somewhere in the middle, but this is a rough guesstimate. Nitrous

oxide is brief acting, but it too may be dangerous; it is also

known to damage both central and peripheral nerves by depleting

vitamin B12



Some people may be more susceptible to Olney's lesions than others.

There is, to my knowledge, NO way of knowing how susceptible you are.



In addition to brain damage, these drugs can also trigger psychosis,

limbic seizures, temporal lability, depression, and other neurological

and psychological diseases much more frequently than other types of

drugs. The dissociatives can be highly addictive to a minority of

users. In comparison, the marijuana and the serotonergic psychedelics

(LSD, psilocybin mushrooms, peyote, DMT) are many times safer.



People who have used dissociatives heavily have shown clear evidence

of brain damage. This is not necessarily conclusive, since the people

who become addicted to them might have underlying conditions

(specifically, temporal lobe complex partial seizures) which could be

responsible for some of the damage. Nonetheless, I can't ignore the

fact that most everyone who uses dissociatives both frequently and

heavily ends up with some sort of neurological or psychological

problem, ranging from impaired memory to a schizophrenia-like

syndrome. Many of the impairments correspond exactly to the areas of

the brain damaged in lab animals.



If you will not abstain from using dissociatives, there are several

steps you can take to protect your brain, ranging from limiting

frequency and dosage to taking nutrients and neuroprotective drugs.

You can also use alternative methods (ranging from safer drugs to

meditation) to reach the same places that dissociatives take you.
KronicKilla Reviewed by KronicKilla on . Whats DXM When you guys are talking about DXM do you mean you just drink cough medicine? I know people who have done that and puked. Do some of you take it a pill form or somthin? Rating: 5