Thinkin about killing myself

[beachguy in thongs]

Hey, there still hope.

http://news.yahoo.com/s/space/200602...elprodentscope

Of Mice and Bullies: Scientists Help Rodents Cope

Bjorn Carey
LiveScience Staff Writer
LiveScience.com Thu Feb 9, 5:00 PM ET

Scientists have tinkered with the genes in mice brains to help them cope with depression and stress.


The alterations work just as well as giving the rodents antidepressant medications normally prescribed to humans, a new study shows.

The research could eventually lead to new treatments for depressed people.

10 days of bullying

Mice are generally social animals, and they frequently introduce themselves to unfamiliar mice. But if exposed to daily bouts of "social defeat," such as being beat up by a stranger, a mouse will stop approaching unfamiliar mice.

Scientists subjected mice to 10 straight days of such bullying and found that the defeated mice avoided bullies even four weeks after their initial beating.

In fact, they were so traumatized that they avoided all other mice as wellâ??even those that were smaller and more docile.

"For both mice and men, social status is important; for mice, losing to a dominant mouse usually means that they avoid the dominant and they avoid social situations," said Thomas Insel of the National Institute of Mental Health.

When researchers gave the mice the human antidepressant drugs Prozac or Tofranil, social interaction improved. The treatment resembled that for depressed humans, said the study's senior author Eric Nestler of the University of Texas Southwestern Medical Center.

Scientists noticed that defeated mice had increased amounts of a gene called BDNF in a region of their brains involved in social memory. BDNF helps regulate the neurotransmitter dopamine, a chemical that carries signals from one nerve cell to another along the brain's reward pathway.

By removing this gene, researchers found mice could be bullied endlessly and not become depressed or socially withdrawn.

"Removal of BDNF before bullying, or treatment with antidepressants after bullying, both removed the behavioral abnormality observed," Nestler told LiveScience.

Help for humans?

Lacking this response, however, could make these mice more susceptible to being bullied in the wild.

"Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond appropriately," Nestler said.

Despite this and other possible negative effects of totally inhibiting BDNF, the research could lead to new antidepressant drugs for humans.

"The challenge is to find a way to inhibit BDNF signaling within the reward pathway specifically," Nestler said. "The many genes we show that are regulated by BDNF or antidepressants in this pathway may provide clues."

This research is detailed in the Feb. 10 issue of the journal Science.

beachguy in thongs Reviewed by beachguy in thongs on 02-10-2006. Thinkin about killing myself why? fuck it, that's why. I remember in high school they gave these stupid seminars on suicide telling us "people commit suicide because they want the pain to stop". well they're fucking stupid, because there's always more than one reason, and sometimes it may even be justified. I hate people who say "it's never the answer". well maybe sometimes it is, maybe the world isn't a big happy simple place where one answer fits all. And right now I realized that it may be my only choice left because I Rating: 5

[STDzRus]

DO IT!! I DARE YOU!! DO IT!!

They say this technique always works.

[LauraCandidi]

I feel like killing myself sometimes




I live in Vernon BC

[da haze meister]

man... suicide is not the answer
were all here for ya!
also if you off yourself... its another thing the gov't can say
weed makes ppl commit suicide.
fuck that shit!
take ten acid hits
that'll make you see the afterlife

[Crispyfried]

Alright dude, I know how you feel. But shit happens to everybody, so don't let stupid modern society crap get to you. I finished college, only to find out that I still couldn't get a decent job, and so I have to go back to school, but screwed up a test so have to at least wait a year. And I tried sitting at home playing videogames, and it made things a lot worse for me and I really felt suicidal, and well let's just not think about that. Get into the mindset of how people have lived for most of human history, before modern society caused all these problems. Maybe consider joining something like the Peace Corps and getting out to the undeveloped world, where they are keeping it real.

[Skink]

Dude... Try and sue the fucked up judo instructors for fucking up your life...

[CocaCola]

EDIT: Yeah, man... life is good.

It can always get good again and it's worth it to stick through until then.

[Aristotle]

Beat the shit out of some kid in an alley. No joke. Worst case scenario is you get in trouble, spend maybe a week in jail, realize how good you have it compared to the people in jail and you get a lot of your back by beating up the kid.

Don't just beat up any kid. Make sure he fits the description of a person you would absolutely despise. No weapons. Just fists. Maybe a shard of glass if the kid gets frisky.

[Smokey McPot]

move to one of the caribbean islands and get a job like taking tourists on snorkel trips or somthin. Who cares if you dont make alota money because if i lived down there with a fun job that would be better than living in ohio making more.

[RastaKaze]

why? fuck it, that's why. I remember in high school they gave these stupid seminars on suicide telling us "people commit suicide because they want the pain to stop". well they're fucking stupid, because there's always more than one reason, and sometimes it may even be justified. I hate people who say "it's never the answer". well maybe sometimes it is, maybe the world isn't a big happy simple place where one answer fits all. And right now I realized that it may be my only choice left because I have nowhere left to go.

right now I'm in college and as it's goin, I'm not going to pass. I've been studying for hours, but no matter how hard I try it's too much and I keep falling behind. it doesn't matter what I do, I've tried and tried, but I can't do it. I'm so fucking sick of people telling me that i just need to buckle down, and it'll be hard, but I'll suceed in the end. pretty fucking words don't pass my tests, don't finish my projects, don't make me understand all the material and catch up. I can work my ass off 24 hours a day, but I'm not gonna pass.

but hey, no big deal right? I'll just drop out, get a job, finally move out, and live a little first. oh wait, nope I'm fucked there too because I'm in so much fuckin pain all the time I can't possibly work. it hurts like hell for me just to take the bus to school, 3 hours a day sitting in class is enough alone to put me in a world of pain. so obviously, I can't go out and work, because I can barely manage to go out shopping.

so hey, if I should disappear suddenly, that's why, because I can't see a fucking way out. I can't finish college, I can't work, i can't move out, and my parents will never let me just sit at home doing nothing. What the hell else do I have for options? NOTHING. there's absolutely no other course I could take that I can see. don't listen to these assholes that say "suicide is NEVER the answer", 'cause I'm living proof that it's the only answer sometimes. I'm not saying I'll pop myself off today, 'cause I'm not, but I imagine I'll have to do it pretty soon.

Mrdevious... you always struck me as one of the more intelligent people on this site... suicide... suicide is not an intelligent idea. Chances are you are going to get alot of nasty replies just because no one wants to here about this "bullshit" but I think we all have times in our life in which we feel similar if not exactly on point with how you feel now. I agree with bedake. The weed can definitely cloud things, try quitting for a week, just seven days. It's been proven a depressent. You'd be amazed the amount of shit you realize after a good week of being sober