I've run a HDD originally on an AMD in a PC with an Intel, so I assume it could work going from an Intel to an AMD. I don't understand what you're saying about the BIOS. I'm upgrading the Mobo. Each mobo has it's own BIOS. Nothing is screwed up on my registry, other than it being part of a PC that is unable to run with a new mobo, because I'm using my PC right now with my old mobo.