I had sythentic mescaline once or twice, but then again it could have been LSD. The effects were extremely similar to what I've read about peyote.

The only reason I wouldn't take peyote is the possiblity of getting sick. I've sustained cellular, and other physical damage, to my small intestine due to a condition that I have, and cannot afford the risk of doing any more harm. I asked one guy that used to post here, a Native American, how he felt about the "vomiting" factor that some people have with peyote, and he claims that it "cleans you out", and is good for you. That may be true for SOME people, but if something might make me sick, I don't take it. I never got sick from acid, or synthetic psylosybin, mescaline, etc. I'll probably try mushooms some day, and see if they agree with me. I have not had any of the psychedelics for decades, anyway - only cannabis (and none of that for a while now, either, lol).