i also have clinical depression for about 3 or 4 years now. ive also tried lots of meds. including lexapro, seroquel, zoloft and prozac. now im taking remeron and tramadol. the remeron doesnt seem to do anything. but the tramadol really works. i have also been smoking weed even before i had the depression and i can say that it really helps. when i got the depression i noticed that my intake of cannabis has increased dramatically. and i was hooked. i couldnt do anything without smoking first since i didnt have any other medications at that time. now that i already have meds, my cannabis intake has lowered as well as my intake of other drugs such as dxm(cough syrup), and nubain(injectible opoid).