http://serendip.brynmawr.edu/bb/neur...Flannagan.html

from that site:

Pre- and Post-loading can be used to lessen the harmful effects of MDMA. Pre-loading is taking supplements before rolling to help counteract the neurotoxic effects of ecstasy. A common pre- load consists of 200mg of 5-Hydroxytryptophan (5-HTP), up to 100mg of Vitamin B-6, up to 1000mg of Vitamin C, and 100mg of Magnesium. (3) Adding more serotonin to the system can counteract the mechanism through which MDMA damages nerve cells. 5-HTP is the direct precursor to serotonin, and can therefore combat the neurotoxicity of MDMA. Vitamin B-6 helps to convert 5-HTP into serotonin, thereby boosting its effect. Because MDMA is thought to be neurotoxic due to oxidized free radicals, the consumption of the anti-oxidant Vitamin C can also reduce the harmful effects of MDMA. Magnesium is used as a muscle relaxer to minimize involuntary jaw-clenching associated with ecstasy use. A post-load consists of the same supplements except that magnesium is unnecessary. (4) It is also beneficial to drink water during and after the use of ecstasy.