PCP chemistry project

[Bonger]

I am currently doing a project in chemistry on pcp, i have come across lots of information on it already and I know that it is a non-competitive NMDA receptor antagonist. Tje problem is i have to "Explain how the reactive sites aid the chemical in its designated role" and also "Explain, including reactions, how the chemical works." I am completely at a loss trying to figure out how PCP binds to this NMDA receptor. If anyone here has a greater knowledge of chemistry than I, please help a brother out. Thanks!

Bonger Reviewed by Bonger on 01-10-2006. PCP chemistry project I am currently doing a project in chemistry on pcp, i have come across lots of information on it already and I know that it is a non-competitive NMDA receptor antagonist. Tje problem is i have to "Explain how the reactive sites aid the chemical in its designated role" and also "Explain, including reactions, how the chemical works." I am completely at a loss trying to figure out how PCP binds to this NMDA receptor. If anyone here has a greater knowledge of chemistry than I, please help a Rating: 5

[Az.]

Chemistry and Pharmacology
Chemically and pharmacologically it is a member of the family of dissociative anesthetics, which also includes ketamine, tiletamine and high doses of dextromethorphan. Although the primary psychoactive effects of the drug only last hours, total elimination from the body is prolonged, typically extending over weeks.


Chemical structure of PCP. (Image in the PD)[edit]
Medical and Veterinary Use
PCP was first tested after World War I as a surgical anaesthetic. Because of its bad side-effects, it was shelved until the 1950s. It was then patented by Parke-Davis and named Sernyl (supposedly referring to serenity), but was again withdrawn from the market because of side effects. It was soon renamed Sernylan, and marketed as a veterinary anaesthetic, but again discontinued. Its side effects and long half-life in the human body made it unsuitable for medical applications. It is retained in fatty tissue and is broken down by the human metabolism into PCHP, PPC and PCAA. When smoked, some of it is broken down by heat into 1-phenyl-1-cyclohexene (PC) and piperidine.

LOL
http://en.wikipedia.org/wiki/Phencyclidine

hope this helps

wikipedia is the way forward dude
try it...type anything in there and it will most probably have somthing about it...bery good site!!! also has links to other sites n shit

top banana

[Bonger]

That info I already had i got off Wikipedia haha. I love wikipedia it knows all. Im starting to doubt whether it is really known or not exactly how it interacts with the NMDA receptor I cant find anything. I guess im going to have to go talk to my teacher tommorow she will know whats up. Thanks though man.

[Nullific]

I posted a link that explains more than you ever wanted to know about how PCP works in the clone thread you posted in Other Psychotropics.