i haven't heard much of mdma and shroums. i know if someones taking an anti-depressant it'll make the shroums twice as potent (ie taking 2 grams would be the same as four) i imagine it would be a bit more dangerous and might do something similar to this. ilve heard of people ideed having bad trips but that may also have been cause the pills they did weren't the greatest or had other shit in them as well if you know your shit is pur for sure then it should be a bit safer.