It's possible, although I am not familiar with topamax. I use just pot for my migraines. I would certainly be careful what kind of toxic coctail you are whipping up by taking topamax, smoking, and whatever other herbals/drugs you are taking.

For example, I learned I am allergic to T3's because I had a bad reaction to them one night. I phoned my doctor and was told T3's have high amounts of caffiene to offset the drowsiness effects of the codeine. I don't drink coffee or other caffiene laced beverages.

I would suggest you check with a doctor or naturopath with regards to all the medications you are taking and what effect those combinations have on you. If all else fails, just take the pot.