Does Weed Really Harm You??

[Delta9 UK]

my 2 cents,

why doesn't that tar eventually give you cancer like cigarettes do? Well there's a nifty enzyme by the name of CYP1A1 that goes around activating these carcinogens. It's not the only one, but it's the primary one. Anyways, nicotine is known to activate this, but THC however, simply doesn't. This is probably where the lung cancer prevention argument comes from. This definitely isn't the only way, but it's a pathway that i've studied for half a semester this fall for a class. Causes asthma? Haha yeah, when THC dilates your bronchioles and helps you breathe better, that'll definitely cause asthma. I use to carry an inhaler around all the time and had it really really bad when i was in grade school. What's weird is that I've never touched one of those since high school, around the time i started smoking mj.

A+ Post Cytochrome P450? Activated by PAH's? Coolio!

http://www.ncbi.nlm.nih.gov/entrez/q...list_uids=1543

[Delta9 UK]

Found this -

Smoke from tobacco and cannabis contains many of the same carcinogens and tumor promoters [20,21]. However, cannabis and tobacco have additional pharmacological activities, both receptor-dependent and independent, that result in different biological endpoints. Polycyclic aromatic hydrocarbons found in smoke are pro-carcinogens that are converted to carcinogens by the enzymatic activity of the cytochrome P4501A1 oxidase protein (CYP1A1 gene product). Benzo [a] pyrene is converted to its carcinogenic metabolite diol epoxide, which binds to specific hyper-mutable nucleotide sequences in the K-ras oncogene and p53 tumor suppressor [22]. Recent work by Roth et al. demonstrates that THC treatment of murine hepatoma cells caused a dose dependent increase in CYP1A1 gene transcription, while at the same time directly inhibiting the enzymatic activity of the gene product [23]. Thus, despite potentially higher levels of polycyclic aromatic hydrocarbons found in cannabis smoke compared to tobacco smoke (dependent on what part of the plant is smoked), the THC present in cannabis smoke should exert a protective effect against pro-carcinogens that require activation. In contrast, nicotine activates some CYP1A1 activities, thus potentially increasing the carcinogenic effects of tobacco smoke [24].

From here : http://www.harmreductionjournal.com/content/2/1/21

Thanks Khoa for pointing me that way

[caloman88]

Even if marijuana ever did or will cause any problems, there are other ways on consuming less but getting a major stone. Smoke keef, or hashish, a couple of small hits will do you well and you dont have to consume alot because its pretty much pure resin and filled with the Thc that takes the whole bud to smoke.:smokin:

[lazy smoker7]

Well in a way the same way as ciggerates would hurt you IMO. But i think cigs harm u more than weed becase. A cigs dont have any good effect and u fuck up your lungs, and weed has a good effect and probally is better for u cause i like to smoke weed when i have problems with nausea and shit so it helps alot more.. the only bad part is just the tar that the plant material that u inhale to ur lungs.. but there are ways aorund that eating etc.. so seriously i think weed is not bad for you at all.. just about anything is bad for us, like drving a car could kill us faster than the many many years it may take to get cancer or sum shit from smoking weed from all the tar, so i say we should all just light up lol. anyways i guess yes it is bad for u and no its not bad for u at the same time.

[Markass]

Well in a way the same way as ciggerates would hurt you IMO. But i think cigs harm u more than weed becase. A cigs dont have any good effect and u fuck up your lungs, and weed has a good effect and probally is better for u cause i like to smoke weed when i have problems with nausea and shit so it helps alot more.. the only bad part is just the tar that the plant material that u inhale to ur lungs.. but there are ways aorund that eating etc.. so seriously i think weed is not bad for you at all.. just about anything is bad for us, like drving a car could kill us faster than the many many years it may take to get cancer or sum shit from smoking weed from all the tar, so i say we should all just light up lol. anyways i guess yes it is bad for u and no its not bad for u at the same time.

You're not going to get cancer from smoking marijuana.
http://www.thoracic.org/sections/pub...ng-cancer.html

[ocbornandrazd]

smoke ranger this is good info and ur dad being a doc.It has been found not to cause lung cancer though.This is a recent release of this finding.What I respect is being told the truth,good and bad about weed.Yeh,I get a little dingy when smoking.So if a body is going to drink a "cocktail" to "wind down".then what's the deal w/smokin a reefer to "wind down".Personally I would rather have my kids smokin weed then drinking booze,driving around and hiding what they r doing.About the smoke in the lungs,well pnenomia left my lungs scarred from age 3. Also you can overdo anything,all things in moderation.