little something something i found from wikipedia

Only a small amount of ergotamine tartrate is required to produce LSD in large batches. For example, 25 kilograms of ergotamine tartrate can produce 5 or 6 kilograms of pure LSD crystal that, under ideal circumstances, could be processed into 100 million dosage units (at 50 micrograms per dose), more than enough to meet what is believed to be the entire annual U.S. demand for the drug. LSD manufacturers need only create a small quantity of the substance and, thus, enjoy the advantages of ease of concealment and transport not available to traffickers of other illegal drugs, primarily marijuana and cocaine.

Manufacturing LSD is time consuming and dangerous. Relatively sophisticated and expensive laboratory equipment is required, and it takes from 2 to 3 days to produce 30 to 100 grams of pure compound. Some of the reactions necessary may cause significant explosions if not performed properly by a trained organic chemist. It is believed that LSD usually is not produced in large quantities, but rather in a series of small batches. Production of LSD in small batches also minimizes the loss of precursor chemicals in case a synthetic step doesn't work as expected.