Quote Originally Posted by syrrus
Ummm....that sounds like a load of crap. From what ive come to understand salvinorin a is a powerful seretonal inhibitor and hallucinagenic replacement. Science barely knows anything about the drug and has no idea how it affects the brain. They do know that it leaves no lasting affect after it's use besides the profound memory of it's effects. If you hear anything about how salvia works, just be safe and don't believe it because there isn't much research going on about the plant at all short of growers trying to increase potency. Just do your research, like I know this kid that keeps on telling people that the reason that you trip out on LSD is because your brain bleeds and the pressure of the bleeding causes hallucinations. See modern american drug culture is full of 90% bullshit.
Actually, salvia is not as big of a mystery as it once was. I assume you're talkin' about serotonin in that first sentence, in which case your understanding of how salvia works is incorrect. Salvinorin-a (main active ingredient in salvia divinorum) is a kappa opioid receptor agonist, meaning that it binds to the kappa opioid receptors and triggers a response in the cells that those receptors are on. Kappa opioid receptors like most if not all receptors in our bodies have corresponding naturally occuring substances (endogenous ligands) that bind to them, for Kappa opioid receptors those substances are dynorphins.

http://en.wikipedia.org/wiki/Salvia_divinorum

http://www.pubmedcentral.nih.gov/art...medid=12192085