Conclusions: Using the Volcano for pulmonal administration of THC, a delivery is reached that is comparable to smoking, without the presence of degradation products or harmful byproducts in significant amounts. This study confirms that the pulmonary administration of cannabinoids by evaporation certainly has a clinical potential. With the Volcano a safe and effective cannabinoid delivery system seems to be available to patients. Although our current study has concentrated on the delivery of THC it should be noted that other cannabinoids might also have a role to play for some indications.