First off, your friend OD'd on what? Shrooms or Peyote or something? That is pretty fucking ludacris... you'd have to be a reckless jack n ape to OD on something like that. But if it was something else like Coke or seomthing... then there is no comparison to Peyote. It's not dangerous like that at all... it's actually a very safe drug. And about doing it just to get fucked up? I don't personally think that is the right way to do it as it is like syrrus said, a very spiritual experience and you could get more out of it that way. but you could use it just for fun... Mescaline is actually pretty plesent at medium doses. But at high doses you'll probably start tweaking and seeing crazy crazy shit... and then if you get worked up in that stage your brain isn't the part that's in trouble but it's the nervous system that is... so be careful. Sorry for rambling!1