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11-19-2005, 05:23 PM #1OPSenior Member
Question of the Day: Is THC Water Soluble?
I found this at overgrow.com.
kaljukajakas || title:|| ||author:kaljukajakas|| ||forum:8||
Normal dextrin is easy to make at home (heat starch in an oven), cyclodextrins are made using special enzymes or bacteria. I doubt they're are used much for generic applications... But if you want to experiment you could start with something as simple as sugar or glucose to enhance the water solubility of THC: like dissolves like (water is very polar, syrup is less so). Adding surfactants would be the easiest way but I doubt anyone wants foam in their lungs
Dissolving the THC in a bit of alcohol before mixing it with a cyclodextrin solution would be a good idea. Better still, make a concentrated 2:1 cyclodextrin to THC solution in alcohol and then add water. Cyclodextrins might be too insoluble in alcohol though for this to be practical. Additives stabilize a solution, getting stuff to dissolve in the first place is the difficult bit. Shaking a blob of honey oil to get it to dissolve will, of course, take forever.
I doubt this approach will be easy to implement.Beta-cyclodextrins (best suited for THC-like molecules) are not very soluble and since at most one cyclodextrin molecule will complex with one THC molecule the amount of water to be inhaled might be too great. But perhaps you could coax a THC molecule or two into a gamma-cyclodextrin ring. That might work, but this really is too complex stuff for speculation. God knows what the formation constants are...
Weird, I distinctly remember reading somewhere that the solubility of THC is ~100mg/100cc not ~0.1mg as it actually is.
end of quote--------
Tetrahydrocannabinol (THC)
Chemical name (-)-(6aR,10aR)-6,6,9-trimethyl-
3-pentyl-6a,7,8,10a-tetrahydro-
6H-benzo[c]chromen-1-ol
Chemical formula C21H30O2
Molecular mass 314.46 g/mol
Boiling point 200 °C
Solubility 2.8 g/l (water, 23 °C)
CAS number 1972-08-3beachguy in thongs Reviewed by beachguy in thongs on . Question of the Day: Is THC Water Soluble? I found this at overgrow.com. kaljukajakas || title:|| ||author:kaljukajakas|| ||forum:8|| Normal dextrin is easy to make at home (heat starch in an oven), cyclodextrins are made using special enzymes or bacteria. I doubt they're are used much for generic applications... But if you want to experiment you could start with something as simple as sugar or glucose to enhance the water solubility of THC: like dissolves like (water is very polar, syrup is less so). Adding surfactants would be Rating: 5
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